Brucella abortus genes identified following constitutive growth and macrophage infection.

@article{Eskra2001BrucellaAG,
  title={Brucella abortus genes identified following constitutive growth and macrophage infection.},
  author={Linda Eskra and Aurea M O Canavessi and Michael Clay Carey and Gary Splitter},
  journal={Infection and immunity},
  year={2001},
  volume={69 12},
  pages={7736-42}
}
The chronicity of Brucella abortus infection in humans and animals depends on the organism's ability to escape host defenses by gaining entry and surviving inside the macrophage. Although no human vaccine exists for Brucella, vaccine development in other bacteria has been based on deletions of selective nutritional as well as regulatory systems. Our goal is to develop a vaccine for Brucella. To further this aim, we have used a green fluorescent protein (GFP) reporter system to identify… CONTINUE READING

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