Brucella Induces an Unfolded Protein Response via TcpB That Supports Intracellular Replication in Macrophages

@inproceedings{Smith2013BrucellaIA,
  title={Brucella Induces an Unfolded Protein Response via TcpB That Supports Intracellular Replication in Macrophages},
  author={Judith A. Smith and Mike Khan and Diogo D. Magnani and Jerome S Harms and Marina A Durward and Girish Radhakrishnan and Yiping Liu and Gary A. Splitter},
  booktitle={PLoS pathogens},
  year={2013}
}
Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most prevalent zoonosis worldwide. The Brucella intracellular replicative niche in macrophages and dendritic cells thwarts immune surveillance and complicates both therapy and vaccine development. Currently, host-pathogen interactions supporting Brucella replication are poorly understood. Brucella fuses with the endoplasmic reticulum (ER) to replicate, resulting in dramatic restructuring of the ER. This ER… CONTINUE READING
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