Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum

@article{Celli2003BrucellaEM,
  title={Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum},
  author={Jean Celli and Chantal de Chastellier and Don-Marc Franchini and Javier Pizarro-Cerd{\'a} and Edgardo Moreno and Jean-Pierre Gorvel},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={545 - 556}
}
The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and replicate inside host macrophages, yet the underlying mechanisms and the nature of the replicative compartment remain unclear. Here we show in a model of Brucella abortus infection of murine bone marrow-derived macrophages that a fraction of the bacteria that survive an initial macrophage killing… CONTINUE READING
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