Brr2p RNA helicase with a split personality: insights into structure and function.

@article{Hahn2010Brr2pRH,
  title={Brr2p RNA helicase with a split personality: insights into structure and function.},
  author={Daniela Hahn and Jean D. Beggs},
  journal={Biochemical Society transactions},
  year={2010},
  volume={38 4},
  pages={
          1105-9
        }
}
RNA helicases are involved in many cellular processes. Pre-mRNA splicing requires eight different DExD/H-box RNA helicases, which facilitate spliceosome assembly and remodelling of the intricate network of RNA rearrangements that are central to the splicing process. Brr2p, one of the spliceosomal RNA helicases, stands out through its unusual domain architecture. In the present review we highlight the advances made by recent structural and biochemical studies that have important implications for… CONTINUE READING

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