Brownian dynamics simulations of interaction between scorpion toxin Lq2 and potassium ion channel.

@article{Cui2001BrownianDS,
  title={Brownian dynamics simulations of interaction between scorpion toxin Lq2 and potassium ion channel.},
  author={M. C. Cui and Jana K. Shen and James M. Briggs and Xiao Min Luo and X Tan and Hua Liang Jiang and Kai Xian Chen and Ru Yun Ji},
  journal={Biophysical journal},
  year={2001},
  volume={80 4},
  pages={1659-69}
}
The association of the scorpion toxin Lq2 and a potassium ion (K(+)) channel has been studied using the Brownian dynamics (BD) simulation method. All of the 22 available structures of Lq2 in the Brookhaven Protein Data Bank (PDB) determined by NMR were considered during the simulation, which indicated that the conformation of Lq2 affects the binding between the two proteins significantly. Among the 22 structures of Lq2, only 4 structures dock in the binding site of the K(+) channel with a high… CONTINUE READING

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