Brownian Dynamics Computational Model of Protein Diffusion in Crowded Media with Dextran Macromolecules as Obstacles

@article{Blanco2017BrownianDC,
  title={Brownian Dynamics Computational Model of Protein Diffusion in Crowded Media with Dextran Macromolecules as Obstacles},
  author={Pablo M. Blanco and Mireia Via and Josep Llu{\'i}s Garc{\'e}s and Sergio Madurga and Francesc Mas},
  journal={Entropy},
  year={2017},
  volume={19},
  pages={105}
}
The high concentration of macromolecules (i.e., macromolecular crowding) in cellular environments leads to large quantitative effects on the dynamic and equilibrium biological properties. These effects have been experimentally studied using inert macromolecules to mimic a realistic cellular medium. In this paper, two different experimental in vitro systems of diffusing proteins which use dextran macromolecules as obstacles are computationally analyzed. A new model for dextran macromolecules… CONTINUE READING
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