Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats.

@article{Blumberg1997BrownFT,
  title={Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats.},
  author={Mark S. Blumberg and Greta Sokoloff and Robert Francis Kirby},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 2},
  pages={
          R1308-13
        }
}
Infants rats depend on heat production by brown adipose tissue (BAT) during cold challenge. Although it has been suggested that BAT thermogenesis protects the heart in the cold, the relationship of BAT activation to cardiac rate has not been examined directly. In the first experiment, the cardiac rate of 2- and 7- to 8-day-old rat pups was monitored during moderate and extreme cold challenge. Pups at both ages maintained cardiac rate during moderate cold challenge while BAT thermogenesis was… 
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Further evidence that BAT thermogenesis modulates cardiac rate in infant rats.
TLDR
The hypothesis that BAT thermogenesis contributes directly to the modulation of cardiac rate is supported by the results of these studies.
Further evidence that BAT thermogenesis modulates cardiac rate in infant rats.
TLDR
The hypothesis that BAT thermogenesis contributes directly to the modulation of cardiac rate is supported by the results of these studies.
Thermoregulatory and cardiac responses of infant spontaneously hypertensive and Wistar-Kyoto rats to cold exposure.
TLDR
It is hypothesized that long-term thermoregulatory deficits during the early postnatal period influence cardiovascular function and contribute to the development of hypertension in SHR.
Active sleep in cold-exposed infant Norway rats and Syrian golden hamsters: the role of brown adipose tissue thermogenesis.
TLDR
The results support the hypothesis that myoclonic twitching is sensitive to the prevailing air temperature and the activation of BAT thermogenesis.
Active sleep in cold-exposed infant Norway rats and Syrian golden hamsters: the role of brown adipose tissue thermogenesis.
TLDR
The results support the hypothesis that myoclonic twitching is sensitive to the prevailing air temperature and the activation of BAT thermogenesis.
Ontogeny of cardiac rate regulation and brown fat thermogenesis in golden hamsters (Mesocricetus auratus)
  • M. Blumberg
  • Biology
    Journal of Comparative Physiology B
  • 1997
TLDR
The hypothesis that heat produced by BAT helps to warm the heart and thus aids in the maintenance of cardiac rate during cold exposure is supported.
Dynamics of Brown Fat Thermogenesis in Week-Old Rats: Evidence of Relative Stability during Moderate Cold Exposure
TLDR
Examination of the relative stability of brown adipose tissue thermogenesis during brief perturbations of air temperature in week-old rats suggests that the response to perturbation is more stably controlled than has previously been suspected.
Neural and hormonal control of arterial pressure during cold exposure in unanesthetized week-old rats.
  • M. Blumberg, T. Knoot, R. Kirby
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2001
TLDR
At 17 degrees C, ultrasonic vocalizations were accompanied by significant increases in MAP, replicating a previous finding and supporting the hypothesis that the vocalization is the acoustic by-product of the abdominal compression reaction, a maneuver that helps to maintain venous return during cardiovascular challenge.
Leptin disinhibits nonshivering thermogenesis in infants after maternal separation.
TLDR
It is shown that leptin disinhibits BAT thermogenesis during cold exposure in infant rats after 18 h of maternal separation, demonstrating that leptin is more than simply an adipostat for the regulation of body weight; specifically, leptin modulates thermogenesis and energy utilization in the early postnatal period.
Leptin disinhibits nonshivering thermogenesis in infants after maternal separation.
TLDR
It is shown that leptin disinhibits BAT thermogenesis during cold exposure in infant rats after 18 h of maternal separation, demonstrating that leptin is more than simply an adipostat for the regulation of body weight; specifically, leptin modulates thermogenesis and energy utilization in the early postnatal period.
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