Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice.

@article{OkamatsuOgura2007BrownFU,
  title={Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice.},
  author={Yuko Okamatsu-Ogura and Naoya Kitao and Kazuhiro Kimura and Masayuki Saito},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 4},
  pages={
          E1135-9
        }
}
The activity of brown adipose tissue (BAT), a site of nonshivering metabolic thermogenesis, has been reported to increase after interleukin (IL)-1beta/lipopolysaccharide injection. To clarify the possible contribution of BAT thermogenesis to whole body febrile response, we investigated febrile and thermogenic response to IL-1beta using mice deficient in uncoupling protein-1 (UCP1), a key molecule for BAT thermogenesis. In wild-type (WT) mice, IL-1beta injection (5 microg/kg ip) increased body… 
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