Brown and Goldstein: the cholesterol chronicles.

  title={Brown and Goldstein: the cholesterol chronicles.},
  author={Prashant Nair},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 37},
When his parents took three-year-old John Despota to his primary care physician in Chicago in 1964, orange-tinted fat-laden bumps lined the skin on the back of his lower legs. Eruptions caused by excess cholesterol, the bumps spread across Despota’s body, mirroring a total blood cholesterol level that hovered above six-times the normal range. By age 12, Despota experienced shortness of breath upon slight exertions, frequent fatigue, and chest pain: cardinal signs of a cardiac illness called… CONTINUE READING