Brown and Beige Fat: Physiological Roles beyond Heat Generation.

  title={Brown and Beige Fat: Physiological Roles beyond Heat Generation.},
  author={S. Kajimura and B. Spiegelman and P. Seale},
  journal={Cell metabolism},
  volume={22 4},
  • S. Kajimura, B. Spiegelman, P. Seale
  • Published 2015
  • Biology, Medicine
  • Cell metabolism
  • Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that… CONTINUE READING
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