Brown adipose tissue and thermogenesis

@article{Fenzl2014BrownAT,
  title={Brown adipose tissue and thermogenesis},
  author={Anna Fenzl and Florian W. Kiefer},
  journal={Hormone Molecular Biology and Clinical Investigation},
  year={2014},
  volume={19},
  pages={25 - 37}
}
  • A. Fenzl, F. Kiefer
  • Published 1 July 2014
  • Medicine, Biology
  • Hormone Molecular Biology and Clinical Investigation
Abstract The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). This process is mediated by the major thermogenic factor uncoupling protein-1 and can be activated by certain stimuli… 
Browning and thermogenic programing of adipose tissue.
  • F. Kiefer
  • Biology, Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2016
TLDR
Recent advances in the understanding of the molecular and physiological mechanisms of adipose tissue browning are discussed, which hold great promise as a novel therapeutic concept against obesity and related complications.
Signaling Pathways Regulating Thermogenesis
TLDR
Several major pathways, β3-adrenergic, insulin/IGF1, thyroid hormone and TGFβ family, which regulate thermogenesis and browning of WAT are discussed.
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TLDR
Presence of brown adipose tissue (BAT), characterized by the expression of the thermogenic uncoupling protein 1 (UCP1), has recently been described in adult humans and Stimulation of BAT activity and/or recruitment of UCP1-positive cells are relevant targets for the treatment of obesity/type 2 diabetes in humans.
The significance of beige and brown fat in humans
TLDR
This review summarizes the current knowledge about the various cellular and molecular aspects of human BAT as well as the relevance for energy metabolism including its therapeutic potential for obesity.
Parathyroid hormone induces a browning program in human white adipocytes
TLDR
It is demonstrated here that PTH is a novel mediator of human adipocyte browning, suggesting a hitherto unknown endocrine axis between the parathyroid gland and adipose tissue in humans.
Browning of Adipose Tissue and Sirtuin Involvement
TLDR
Sirtuin1 (SIRT1), the most known isoform of sirtuin deacetylases, is implied in the browning of WAT process and is a sensitive sensor of cell energy metabolism and contributes to this differentiation process.
The Effect of Exercise on Beige Adipose Tissue
Obesity leads to metabolic diseases, and adipose tissue is considered one of the regulators of metabolism. Recent researches have demonstrated that some stimulants cause beige subcutaneous adipose
White, beige and brown adipose tissue: structure, function, specific features and possibility formation and divergence in pigs
Introduction. Traditionally, mammalian adipose tissue is divided into white (white adipose tissue – WAT) and brown (brown adipose tissue – BAT). While the functions of WAT are well known as the
The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue
TLDR
The role of AMPK is discussed, emphasizing its role in the energy expenditure of brown/beige adipose tissue and browning of WAT, which can provide new insights into obesity research and treatment.
Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
  • Ya-Nan Duan, Xiang Ge, +5 authors Jingya Li
  • Medicine, Chemistry
    Frontiers in Endocrinology
  • 2020
TLDR
Chronic experiments revealed that mice fed a high-fat diet with 100 mg/kg diphyllin had ameliorated oral glucose tolerance and insulin sensitivity and decreased body weight and fat content ratio and Adaptive thermogenesis in HFD-fed mice under cold stimulation and whole-body energy expenditure were augmented after chronic dip Hyllin treatment.
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References

SHOWING 1-10 OF 170 REFERENCES
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
TLDR
It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.
Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
TLDR
Studying mouse models, it is shown that cyclooxygenase (COX)–2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of β-adrenergic signaling in WAT and is required for the induction of BAT in Wat depots, which suggests that the PG pathway regulates systemic energy homeostasis.
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
TLDR
This protocol describes a mouse model to study the activation of BAT and angiogenesis in adipose tissues by cold acclimation, which results in a lean phenotype in BAT and the molecular mechanisms that control adipose mass.
Brown adipose tissue: function and physiological significance.
TLDR
The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
TLDR
It is demonstrated that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues and reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists.
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization.
TLDR
The results demonstrate that adipocytes expressing UCP are present in adipose deposits considered as white fat, and suggest the existence of a continuum in rodents between BAT and WAT, and a great plasticity between adipose tissue phenotypes.
Identification and importance of brown adipose tissue in adult humans.
TLDR
Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Adaptive thermogenesis in adipocytes: is beige the new brown?
TLDR
A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.
Functional thermogenic beige adipogenesis is inducible in human neck fat
TLDR
Beige adipocytes are thermogenic in humans and FGF21 is a beige adipokine capable of promoting a brown fat-like thermogenic program in WAs, providing first evidence of inducible functional thermogenic bege adipogenesis in human neck fat.
Anatomical Localization, Gene Expression Profiling, and Functional Characterization of Adult Human Neck Brown Fat
TLDR
This study isolated anatomically defined neck fat from adult human volunteers and compared its gene expression, differentiation capacity and basal oxygen consumption to different mouse adipose depots, suggesting that activation of human BAT could be used as a safe treatment for obesity and metabolic dysregulation.
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