Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): analysis of the elicitation dose-response relationship.

@article{Pauluhn2008BrownNR,
  title={Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): analysis of the elicitation dose-response relationship.},
  author={Juergen Pauluhn},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={104 2},
  pages={
          320-31
        }
}
The known human asthmagen polymeric diphenylmethane-diisocyanate (MDI) was investigated in the Brown Norway rat skin asthma model. Two types of dose-response relationships are addressed with the following focus: (1) does sensitization dose and surface area influence the subsequent elicitation response and (2) is the elicitation response more dependent on previous elicitation doses or more on skin sensitizing dose? These two aims are investigated in two elaborated experiments, using inflammatory… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Deutsche Forschungsgemeinschaft (DFG)—MAK- und BAT-Wert-Liste

  • DFG-MAK.
  • Senatskommission zur Prüfung gesundheitssch…
  • 2007

Similar Papers

Loading similar papers…