• Corpus ID: 53654835

Brown Algae as A Golden Mine For Treatment of Liver Fibrosis : A Proposal Based on Experimental Animal Study

@inproceedings{Hegazi2015BrownAA,
  title={Brown Algae as A Golden Mine For Treatment of Liver Fibrosis : A Proposal Based on Experimental Animal Study},
  author={Hegazi},
  year={2015}
}

• Hegazi
• Published 2015
• Biology

Over the years, marine algae species offer a biological diversity in discovery-phase of new strategy for treatment of several diseases. Interest in seaweed has been on the rise, owing to the recognition of important bioactive molecules. The present study was constructed to explore the potential effectiveness of two species of brown marine algae Cystoseira myrica and Padina pavonica in regression of liver fibrosis in the experimental model. Treatment of liver fibrosis bearing rats with either fresh or dry methanolic extract of Cystoseira myrica and Padina pavonica revealed significant suppression of liver fibrosis. This finding was evidenced by the decreased urinary lamnine, and 8-Hydroxydeoxyguanosine (8-OHdG) levels, as well as hepatic malondialdehyde (MDA) content, serum hepatocyte growth factor (HGF), nuclear factor kappa-B (NF κB) and interleukin 8 (IL-8) levels, in concomitant with the increased hepatic paraxonase-1(PON-1) activity. Additionally, Cystoseira myrica and Padina pavonica extracts could downregulate the expression of Bcl2, KI-67 and transforming growth factorβ (TGF-β) in the liver of the treated rats as documented via immunohistochemical examination. These encouraging results provide new concepts for the development of natural therapeutic opportunities from brown marine algae in the management of liver fibrosis through their antioxidant, anti-inflammatory and antiproliferative activity.