Brown Adipose Tissue , Β 3-adrenergic Receptors , and Obesity

  title={Brown Adipose Tissue , Β 3-adrenergic Receptors , and Obesity},
  author={Bradford B. Lowell and Jeffrey S. Flier},
Brown adipose tissue is distinguished by its unique capacity for uncoupled mitochondrial respiration, which is highly regulated by sympathetic nerve activity. Because of this, energy expenditure in brown fat is capable of ranging over many orders of magnitude. The fact that the function of brown adipose tissue is impaired in obese rodents and that transgenic mice with decreased brown fat develop obesity demonstrates the importance of brown fat in maintaining nutritional homeostasis. However… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 74 references

Activation ofβ3-adrenergic recep tors suppresses leptin expression and medi- ates a leptin-independent inhibition of food intake

  • CS Mantzoros, D Qu, RC Frederich
  • 1996
1 Excerpt

Brown Adipose Tissue

  • P Jezek, J Hanus, C Semrad, KD. Garlid
  • 1996

Generation of mice expressing human but notmurineβ3-adrenergic receptors

  • M Ito, D Grujic, VS Susulic
  • In 10th Int. Congr. Endocrinol.(Abstr.)
  • 1996
1 Excerpt

Similar Papers

Loading similar papers…