Bronchoscopic lung volume reduction with a dedicated coil: a clinical pilot study.

Abstract

BACKGROUND Lung volume reduction aims to improve symptoms by reducing hyperinflation. Endoscopic approaches so far have generally been hampered in their efficacy by collateral ventilation (CV). We sought to determine the safety and feasibility of a new endoscopic lung volume reduction approach independent of the effects of CV. METHODS Patients with severe emphysema were eligible. Inclusion and exclusion criteria were modeled after the National Emphysema Treatment Trial (NETT) study. Homogenous and heterogeneous disease was allowed. Treatment consisted of the placement of coils into the parenchyma of the most diseased area with the intent of achieving parenchymal compression. Primary endpoints were safety and feasibility assessments. Secondary endpoints were efficacy outcomes. RESULTS Eleven patients underwent 21 procedures. Procedures were performed under general anesthesia and lasted 45+/-15 minutes and per procedure 4.9+/-0.6 coils were placed. All procedures were well tolerated. The total follow-up time was 7-11 months and in that time 33 adverse events were reported, none of them severe. No pneumothorax occurred. Efficacy seemed better in heterogeneous rather than homogenous disease. CONCLUSION Endoscopic lung volume reduction with coils is safe and feasible. Further studies of the efficacy are indicated.

DOI: 10.1177/1753465810368553
05010020102011201220132014201520162017
Citations per Year

305 Citations

Semantic Scholar estimates that this publication has 305 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Herth2010BronchoscopicLV, title={Bronchoscopic lung volume reduction with a dedicated coil: a clinical pilot study.}, author={Felix J. F. Herth and Ralf Eberhard and Daniela Gompelmann and Dirk-Jan Slebos and Armin Ernst}, journal={Therapeutic advances in respiratory disease}, year={2010}, volume={4 4}, pages={225-31} }