Bronchopulmonary dysplasia

  title={Bronchopulmonary dysplasia},
  author={John P. Kinsella and Anne Greenough and Steven H. Abman},
  journal={The Lancet},
Bronchopulmonary dysplasia is a chronic lung disease that affects premature babies and contributes to their morbidity and mortality. Improved survival of very immature infants has led to increased numbers of infants with this disorder. This increase puts a heavy burden on health resources since these infants need frequent re-admission to hospital in the first 2 years after birth and, even as adolescents, have lung-function abnormalities and persistent respiratory symptoms. Unlike the original… Expand
Bronchopulmonary dysplasia.
The primary focus of all treatment associated with premature infants is on prevention of BPD, which is targeted at minimizing effects of this pulmonary disease and preventing the long-term sequelae associated with its treatment. Expand
Bronchopulmonary dysplasia: an old and new disease
To date, BPD represents not only a chronic pulmonary pathology in infancy that prevalently affects premature neonates who undergo mechanical ventilation and oxygen therapy for respiratory distress syndrome (RDS), but also prematures with minor signs of initial pulmonary pathology or term neonates requiring aggressive ventilatory support due to an acute and severe lung pathology. Expand
Bronchopulmonary dysplasia: definitions and long-term respiratory outcome.
Recent changes in the definition of BPD are discussed, the main differences between the old and the new form are discussed and recent data on long-term respiratory outcome is summarized. Expand
Lifelong pulmonary sequelae of bronchopulmonary dysplasia.
Long-term longitudinal studies are needed to determine if recent survivors of BPD will also be at increased risk of debilitating pulmonary disease in adulthood, and subtle differences in exercise tolerance and activity may put survivors with BPD at further risk of future morbidity in later life. Expand
Lung Transplantation for Bronchopulmonary Dysplasia in Adults
Three adult patients who underwent recent lung transplantation for BPD from 2 institutions were identified and common pathologic features including hyperexpanded lungs with air trapping and mosaic attenuation on chest computed tomographic scan, severe obstructive changes on pulmonary function test, and pulmonary hypertension were shown. Expand
Bronchopulmonary Dysplasia and Oxidative Stress in the Newborn
This chapter focuses on the role of OS on the lung injury and analyzes the most recent biomarkers in clinical studies. Expand
Screening for pulmonary hypertension in preterm infants—not ready for prime time
The principles of screening and how to evaluate the utility of screening tests are described, the evidence for screening for PH in preterm infants with and without BPD is summarized, and it is proposed that it is premature to routinely start screening all pre term infants or infants with BPD for PH. Expand
The evolution of disease: chronic lung disease of infancy and pulmonary hypertension
A brief historical perspective on BPD is provided; and an update relative to current notions of epidemiology, pathophysiology, evaluation, and clinical management of BPD complicated by vascular disease is provided. Expand
Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse?
The state of the art research developments in regards to antioxidants and premature lung disease are summarized and the limitations of antioxidant therapies are discussed in order to more fully comprehend the reasons why therapeutic antioxidant administration failed to prevent BPD. Expand
[The role of pulmonary hypertension on bronchopulmonary dysplasia].
Considering the high mortality in BPD associated PH, screening strategies in at risk population become important and transtho-rathic echocardiography is a useful tool for the screening and diagnosis of PH in displasic patients. Expand