Bronchoprotective role for endogenous prostaglandin E2

@article{Pavord1995BronchoprotectiveRF,
  title={Bronchoprotective role for endogenous prostaglandin E2},
  author={Ian D. Pavord and Anne E. Tattersfield},
  journal={The Lancet},
  year={1995},
  volume={345},
  pages={436-438}
}
The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction at concentrations known to occur in the airway; inhalation of PGE2 has considerable bronchoprotective effects in patients with asthma; and… CONTINUE READING

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