Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients.

@article{Grove1995BronchodilatorST,
  title={Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients.},
  author={Alison Grove and Brian J Lipworth},
  journal={Lancet},
  year={1995},
  volume={346 8969},
  pages={201-6}
}
In view of current concerns about use of regular beta-2 agonists, and the place of the newer long-acting drugs, we decided to evaluate whether continuous exposure to twice daily salmeterol results in a blunting of the acute bronchodilator response to repeated doses of salbutamol, as might be administered in the management of an acute asthma attack. After a… CONTINUE READING