Bronchodilator activity of dimaprit in the guinea pig in vitro and in vivo.


The bronchodilator activity of the H2-recptor agonist, dimaprit, was assessed in vitro and in vivo. In vitro dimaprit relaxed guinea pig tracheal spirals and parenchymal strips that were constricted by the H1 receptor agonist, 2-PEA, or by carbachol. The H2-receptor antagonist, metiamide, inhibited this effect of dimaprit in vitro on both tissues constricted by 2-PEA but not on the carbachol constricted tracheal spiral. Intravenous infusion of dimaprit in the intact guinea pig resulted in reversal of bronchoconstriction induced by subcutaneous injection of 2-PEA. In vivo pretreatment with the H2-recptor antagonist, metiamide, resulted in a diminished sensitivity to the bronchodilating effects of intravenous dimaprit.


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@article{Drazen1979BronchodilatorAO, title={Bronchodilator activity of dimaprit in the guinea pig in vitro and in vivo.}, author={Jeffrey M . Drazen and Martin W Schneider and C. S. Venugopalan}, journal={European journal of pharmacology}, year={1979}, volume={55 3}, pages={233-9} }