Bronchodilator activity of a nonxanthine phosphodiesterase inhibitor; 2,4-diamino-5-cyano-6-bromopyridine (compound I).

Abstract

The ability of 2,4-diamino-5-cyano-6-bromopyridine (compound 1) to inhibit bronchiolar smooth muscle constriction was examined in isolated rings of rabbit primary bronchi and intrapulmonary bronchioles. After carbachol-induced constriction these tissue were significantly relaxed by either compound I or 1-methyl-3-isobutylxanthine (MIX) in a similar dose… (More)

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@article{Smith1986BronchodilatorAO, title={Bronchodilator activity of a nonxanthine phosphodiesterase inhibitor; 2,4-diamino-5-cyano-6-bromopyridine (compound I).}, author={Paul W. Smith and W. J. Thompson and Christoph de Ha{\"e}n and Marilyn J. Halonen and J. D. Palmer and D. G. Johnson}, journal={The Journal of pharmacology and experimental therapeutics}, year={1986}, volume={237 1}, pages={114-9} }