Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate.

@article{Fabbri1987BronchoalveolarND,
  title={Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate.},
  author={Leo M Fabbri and Piera Boschetto and E Zocca and G F Milani and F Pivirotto and Mario Plebani and Angelo Burlina and B Licata and Cristina Elisabetta Mapp},
  journal={The American review of respiratory disease},
  year={1987},
  volume={136 1},
  pages={36-42}
}
The mechanism by which late asthmatic reactions are induced by toluene diisocyanate (TDI), a low molecular weight chemical that causes occupational asthma in exposed subjects, is unknown. We investigated whether early and late asthmatic reactions induced by TDI are associated with changes in airway responsiveness to methacholine and airway inflammation as determined by bronchoalveolar lavage. We measured FEV1 before and at regular intervals after exposure to TDI, and performed dose-response… CONTINUE READING