Bronchoalveolar leukocyte response in experimental silicosis: modulation by a soluble aluminum compound.

@article{Brown1989BronchoalveolarLR,
  title={Bronchoalveolar leukocyte response in experimental silicosis: modulation by a soluble aluminum compound.},
  author={Geraldine M. Brown and Ken Donaldson and David M. Brown},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={101 1},
  pages={
          95-105
        }
}
The biological properties of quartz have been related to its surface reactivity. We have addressed the role of particle surface reactivity in mediating the biological activity of quartz in mixed dusts, by treating the quartz with aluminum lactate. Intratracheal instillation of untreated quartz in rats caused a rapid, sustained alveolitis and bronchoalveolar leukocytes obtained from these animals had enhanced activity in degrading fibronectin, but reduced ability to mount a respiratory burst… CONTINUE READING
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