Bronchoalveolar lavage versus bolus administration of lucinactant, a synthetic surfactant in meconium aspiration in newborn lambs.

@article{ReySantano2011BronchoalveolarLV,
  title={Bronchoalveolar lavage versus bolus administration of lucinactant, a synthetic surfactant in meconium aspiration in newborn lambs.},
  author={Carmen Rey-Santano and Francisco Jos{\'e} Alvarez-Diaz and Victoria Eugenia Mielgo and Xabier Murgia and Hector Lafuente and Estibaliz Ruiz-del-Yerro and Adolfo Valls-i-Soler and Elena Gastiasoro},
  journal={Pediatric pulmonology},
  year={2011},
  volume={46 10},
  pages={991-9}
}
This study was designed to study effects of lung lavage versus the classical bolus instillation with a peptide-based synthetic surfactant (lucinactant) in a model of Meconium Aspiration Syndrome (MAS). Eighteen newborn lambs received meconium and were randomized to: the experimental meconium installation (eMAS) group-lambs with eMAS kept on conventional mechanical ventilation (control); the SF-Bolus group-eMAS receiving a lucinactant bolus (30 mg/ml); or the D-SF-Lavage group-eMAS treated with… CONTINUE READING
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Treatment of severe meconium aspiration syndrome with porcine surfactant : a multicentre , randomized , controlled trial

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