Bronchoalveolar lavage fluid from normal rats stimulates DNA synthesis in rat alveolar type II cells.

@article{Leslie1989BronchoalveolarLF,
  title={Bronchoalveolar lavage fluid from normal rats stimulates DNA synthesis in rat alveolar type II cells.},
  author={Christina C. Leslie and Kathleen McCormick-Shannon and Robert J. Mason},
  journal={The American review of respiratory disease},
  year={1989},
  volume={139 2},
  pages={360-6}
}
Proliferation of alveolar type II cells after lung injury is important for the restoration of the alveolar epithelium. Bronchoalveolar lavage fluid (BALF) may represent an important source of growth factors for alveolar type II cells. To test this possibility, BALF fluid was collected from normal rats, concentrated 10-fold by Amicon filtration, and tested for its ability to stimulate DNA synthesis in rat alveolar type II cells in primary culture. BALF induced a dose-dependent increase in type… CONTINUE READING