Bronchiectasis

@article{MacAogin2018Bronchiectasis,
  title={Bronchiectasis},
  author={Miche{\'a}l Mac Aog{\'a}in and James D. Chalmers and Sanjay Haresh Chotirmall},
  journal={Nature Reviews Disease Primers},
  year={2018},
  volume={4},
  pages={1-18}
}
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms of bronchiectasis include persistent bacterial infections, dysregulated immune responses, impaired mucociliary clearance and airway obstruction. These mechanisms can interact and self-perpetuate, leading over time to impaired lung function. Patients commonly present with productive cough and recurrent chest… 
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This review outlines clinical and pre-clinical peer-reviewed research published in the last 5 years, focusing on the pathogenesis of bronchiectasis and the role of P. aeruginosa and its virulence in shaping host inflammatory and immune responses in the airway, and further detail its role in airway infection, the lung microbiome, and address therapeutic options.
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TLDR
This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.
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TLDR
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TLDR
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TLDR
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