author={Miche{\'a}l Mac Aog{\'a}in and James D. Chalmers and Sanjay Haresh Chotirmall},
  journal={Nature Reviews Disease Primers},
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms of bronchiectasis include persistent bacterial infections, dysregulated immune responses, impaired mucociliary clearance and airway obstruction. These mechanisms can interact and self-perpetuate, leading over time to impaired lung function. Patients commonly present with productive cough and recurrent chest… 
Pseudomonas aeruginosa in bronchiectasis: infection, inflammation, and therapies
This review outlines clinical and pre-clinical peer-reviewed research published in the last 5 years, focusing on the pathogenesis of bronchiectasis and the role of P. aeruginosa and its virulence in shaping host inflammatory and immune responses in the airway, and further detail its role in airway infection, the lung microbiome, and address therapeutic options.
Bronchiectasis in Primary Antibody Deficiencies: A Multidisciplinary Approach
The underlying immune deficiency and the bronchiectasis need to be treated from combined immunology and pulmonary perspectives, reflected in this review by experts from both fields.
Paediatric and adult bronchiectasis: Specific management with coexisting asthma, COPD, rheumatological disease and inflammatory bowel disease
The present review aims at summarizing the current knowledge and available evidence on the management of bronchiectasis in the conditions mentioned and focuses on the new therapeutic strategies that are emerging as promising tools for improving patients’ quality of life.
Bronchiectasis with secondary pulmonary infection in a child
Antibiotics and airway clearance techniques represent the milestones of bronchiectasis management although there are only a few guidelines in children.
Respiratory Mycoses in COPD and Bronchiectasis.
The emerging evidence for the clinical importance of fungi in COPD and bronchiectasis, available diagnostic modalities, mycobiome sequencing approaches and association with clinical outcomes are outlined.
Bronchiectasis in Childhood.
Bronchiectasis and cough: An old relationship in need of renewed attention
Bronchiectasis and inhaled tobramycin: A literature review.
Clinical Aspergillus Signatures in COPD and Bronchiectasis
An overview of clinical Aspergillus signatures in COPD and bronchiectasis is provided and the current advances in the understanding of the mycobiome in these disease states are covered.
Association of childhood tracheomalacia with bronchiectasis: a case–control study
While causality cannot be inferred, children with tracheomalacia should be monitored for chronic wet cough, the most common symptom of bronchiectasis, which if present should be treated and then investigated if the cough persists or is recurrent.


Management of bronchiectasis in adults
This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.
Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
In all three conditions, impaired muco‐ciliary clearance seems to be the common risk factor that provides organisms the opportunity to colonize the lower airway, and the principles of managing PBB, CSLD and bronchiectasis are the same.
Protracted bacterial bronchitis: The last decade and the road ahead
Although regarded as having a good prognosis, recurrences are common and if these are frequent or do not respond to antibiotic treatments of up to 4‐weeks duration, the child should be investigated for other causes of chronic wet cough, such as bronchiectasis.
Bronchiectasis: new therapies and new perspectives.
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis
This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis and highlights the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic Differences in the prognosis and management of bron Chiectasis.
An investigation into causative factors in patients with bronchiectasis.
Intensive investigation of this population of patients with bronchiectasis led to identification of one or more causative factor in 47% of cases, and the cause identified had implications for prognosis and treatment.