Bronchial responsiveness and inflammation in guinea-pigs exposed to toluene diisocyanate: a study on single and repeated exposure.

@article{Gagnaire1996BronchialRA,
  title={Bronchial responsiveness and inflammation in guinea-pigs exposed to toluene diisocyanate: a study on single and repeated exposure.},
  author={François Gagnaire and Masarin Ban and Jean Claude Micillino and Marc Lemonnier and Pierre Bonnet},
  journal={Toxicology},
  year={1996},
  volume={114 2},
  pages={91-100}
}
The question of whether or not toluene diisocyanate (TDI)-induced airway hyperresponsiveness in the guinea-pig is accompanied by neutrophil influx into bronchoalveolar lavage fluid (BALF) was addressed. Two modes of exposure were studied; (1) acute exposures where animals were exposed to 3 ppm TDI for 1 h and experiments were carried out 30 min, 4 h, 24 h, 48 h and 1 week after the TDI exposures; (2) subacute exposures where animals were exposed to 0.080 and 0.046 ppm TDI for 48 h 1 week… CONTINUE READING

Similar Papers

Loading similar papers…