Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells.

@article{Schmidt2011BronchialEC,
  title={Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells.},
  author={Lotte M. Schmidt and Maria G Belvisi and Konrad A Bode and Judith Bauer and Claudia Schmidt and M. Suchy and Dimitrios Tsikas and Jutta Scheuerer and Felix Lasitschka and Herman-Josef Gr{\"o}ne and Alexander H Dalpke},
  journal={Journal of immunology},
  year={2011},
  volume={186 4},
  pages={2095-105}
}
Airway epithelial cells regulate immune reactivity of local dendritic cells (DCs), thus contributing to microenvironment homeostasis. In this study, we set out to identify factors that mediate this regulatory interaction. We show that tracheal epithelial cells secrete soluble factors that downregulate TNF-α and IL-12p40 secretion by bone marrow-derived DCs but upregulate IL-10 and arginase-1. Size exclusion chromatography identified small secreted molecules having high modulatory activity on… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…