Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway.

@article{Petecchia2009BronchialAE,
  title={Bronchial airway epithelial cell damage following exposure to cigarette smoke includes disassembly of tight junction components mediated by the extracellular signal-regulated kinase 1/2 pathway.},
  author={Loredana Petecchia and Federica Sabatini and Luigi Varesio and Anna Camoirano and Cesare Usai and Annalisa Pezzolo and Giovanni A Rossi},
  journal={Chest},
  year={2009},
  volume={135 6},
  pages={
          1502-1512
        }
}
BACKGROUND Through a variety of biochemical mechanisms, cigarette smoke (CS) may damage airway epithelium, altering its normal structure and function. Injury to epithelium may include changes in tight junction (TJ) integrity with impairment of epithelial barrier function. METHODS AND RESULTS To study the effect of the exposure to CS condensate (CSC) on TJ integrity, two human bronchial epithelial cell lines (HBECs), BEAS-2B and 16HBE14o-, were used. Exposure of the two HBECs to CSC resulted… CONTINUE READING

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