Bromperidol radioimmunoassay: human plasma levels.

  title={Bromperidol radioimmunoassay: human plasma levels.},
  author={John P. Tischio and Nancy Hetyei and J. Vernon Patrick},
  journal={Journal of pharmaceutical sciences},
  volume={73 4},
A sensitive radioimmunoassay (RIA) procedure was developed to assay for bromperidol levels in human plasma after therapeutic drug administration. The antisera used in the RIA procedure was generated in rabbits against a haloperidol-bovine serum albumin conjugate. Tritiated haloperidol was used as the radioligand in the assay. A single ether extraction of alkalinized plasma was used to separate bromperidol from its more polar metabolites and to reduce assay variability encountered with a direct… CONTINUE READING