Bromovirus RNA replication compartment formation requires concerted action of 1a's self-interacting RNA capping and helicase domains.

@article{Diaz2012BromovirusRR,
  title={Bromovirus RNA replication compartment formation requires concerted action of 1a's self-interacting RNA capping and helicase domains.},
  author={Arturo Tlaca{\'e}lel Curiel Diaz and Andreas Gallei and Paul Ahlquist},
  journal={Journal of virology},
  year={2012},
  volume={86 2},
  pages={821-34}
}
All positive-strand RNA viruses replicate their genomes in association with rearranged intracellular membranes such as single- or double-membrane vesicles. Brome mosaic virus (BMV) RNA synthesis occurs in vesicular endoplasmic reticulum (ER) membrane invaginations, each induced by many copies of viral replication protein 1a, which has N-terminal RNA capping and C-terminal helicase domains. Although the capping domain is responsible for 1a membrane association and ER targeting, neither this… CONTINUE READING