Bromodomain inhibitors and cancer therapy: From structures to applications

  title={Bromodomain inhibitors and cancer therapy: From structures to applications},
  author={Montserrat P{\'e}rez-Salvia and Manel Esteller},
Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes that are "writers," "erasers," or "readers" of histone modification marks are common. Bromodomains are "readers" that bind acetylated lysines in histone tails. Their most important function is the regulation of gene transcription by the recruitment of different… CONTINUE READING

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