Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.

@article{Santillan2006BromodomainAH,
  title={Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.},
  author={Donna A. Santillan and Catherine M Theisler and Amanda S Ryan and Relja Popovic and Tara Stuart and Ming-Ming Zhou and Serhan Alkan and Nancy J. Zeleznik-Le},
  journal={Cancer research},
  year={2006},
  volume={66 20},
  pages={10032-9}
}
A critical unanswered question about mixed lineage leukemia (MLL) is how specific MLL fusion partners control leukemia phenotype. The MLL-cyclic AMP-responsive element binding protein-binding protein (CBP) fusion requires both the CBP bromodomain and histone acetyltransferase (HAT) domain for transformation and causes acute myelogenous leukemia (AML), often preceded by a myelodysplastic phase. We did domain-swapping experiments to define whether unique specificities of these CBP domains drive… CONTINUE READING
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