Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

@article{Gupta2013BromoAE,
  title={Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.},
  author={Saumya Shree Gupta and Tobias Maetzig and Goedele N Maertens and Azar Sharif and Michael Rothe and Magdalena Weidner-Glunde and Melanie Galla and Axel Schambach and Peter Cherepanov and Thomas F Schulz},
  journal={Journal of virology},
  year={2013},
  volume={87 23},
  pages={12721-36}
}
Retroviral integrase (IN) proteins catalyze the permanent integration of proviral genomes into host DNA with the help of cellular cofactors. Lens epithelium-derived growth factor (LEDGF) is a cofactor for lentiviruses, including human immunodeficiency virus type 1 (HIV-1), and targets lentiviral integration toward active transcription units in the host genome. In contrast to lentiviruses, murine leukemia virus (MLV), a gammaretrovirus, tends to integrate near transcription start sites. Here, we… CONTINUE READING

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