Bromines on N-allyl position of cationic porphyrins affect both radio- and photosensitizing properties.

Abstract

With the aim to develop improved dual-action sensitizers suitable for both photodynamic therapy (PDT) and radiotherapy, we prepared a series of metal and metal-free cationic porphyrins, brominated either on beta- or N-allyl positions. Photo- and radiosensitizing efficacy was evaluated in MDA-MB-231 breast cancer cells incubated with 1 muM porphyrin and… (More)
DOI: 10.1039/b812623b

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