Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.

@article{Zhou2003BrominatedDO,
  title={Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.},
  author={Jun Zhou and Kamlesh Gupta and Shefali Aggarwal and Ritu Aneja and Ramesh Chandra and Dulal Panda and Harish C. Joshi},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 4},
  pages={799-807}
}
Noscapine, a microtubule-interfering agent, has been shown to arrest mitosis, to induce apoptosis, and to have potent antitumor activity. We report herein that two brominated derivatives of noscapine, 5-bromonoscapine (5-Br-nosc) and reduced 5-bromonoscapine (Rd 5-Br-nosc), have higher tubulin binding activity than noscapine and affect tubulin polymerization differently from noscapine. In addition, they are able to arrest cell cycle progression at mitosis at concentrations much lower than… CONTINUE READING

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cycle arrest in response to loss of microtubule function

  • MA Jordan, L Wilson
  • 1999
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