Bromelain treatment decreases neutrophil migration to sites of inflammation.

  title={Bromelain treatment decreases neutrophil migration to sites of inflammation.},
  author={David J. Fitzhugh and Siqing Shan and Mark W. Dewhirst and Laura P. Hale},
  journal={Clinical immunology},
  volume={128 1},
Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The purpose of this work was to understand potential mechanisms for this anti-inflammatory activity. Exposure to bromelain in vitro has been shown to remove a number of cell surface molecules that are vital to leukocyte trafficking, including CD128a/CXCR1 and CD128b/CXCR2 that serve as receptors for the… CONTINUE READING
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