Bromazepam pharmacokinetics: Influence of age, gender, oral contraceptives, cimetidine, and propranolol

@article{Ochs1987BromazepamPI,
  title={Bromazepam pharmacokinetics: Influence of age, gender, oral contraceptives, cimetidine, and propranolol},
  author={H. Ochs and D. Greenblatt and H. Friedman and E. Burstein and A. Locniskar and J. Harmatz and R. Shader},
  journal={Clinical Pharmacology & Therapeutics},
  year={1987},
  volume={41}
}
Pharmacokinetics of the benzodiazepine bromazepam were evaluated in volunteer subjects who received single 6 mg oral doses followed by blood sampling during the next 48 hours. Age and gender effects were studied in 32 subjects, divided into young (aged 21 to 29 years) and elderly (aged 60 to 81 years) groups. Compared with young subjects, the elderly had significantly higher peak serum bromazepam concentrations (132 vs. 82 ng/ml), smaller volume of distribution (0.88 vs. 1.44 L/kg), lower oral… Expand
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