Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome

@inproceedings{Sinha2018BrokenRF,
  title={Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome},
  author={Anurag Kumar Sinha and Christophe Possoz and Adeline Durand and Jean-Michel Desfontaines and François-Xavier Barre and David R F Leach and B{\'e}n{\'e}dicte Michel},
  booktitle={PLoS genetics},
  year={2018}
}
It was recently reported that the recBC mutants of Escherichia coli, deficient for DNA double-strand break (DSB) repair, have a decreased copy number of their terminus region. We previously showed that this deficit resulted from DNA loss after post-replicative breakage of one of the two sister-chromosome termini at cell division. A viable cell and a dead cell devoid of terminus region were thus produced and, intriguingly, the reaction was transmitted to the following generations. Using genome… CONTINUE READING

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