Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis.

@article{Papp2012BrodalumabAA,
  title={Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis.},
  author={Kim A Papp and Craig L. Leonardi and Alan Menter and Jean-paul Ortonne and James Glenn Krueger and Gregory Kricorian and Girish A. Aras and Juan Li and Chris B. Russell and Elizabeth Heather Thompson and Scott Edward Baumgartner},
  journal={The New England journal of medicine},
  year={2012},
  volume={366 13},
  pages={
          1181-9
        }
}
BACKGROUND In this phase 2, randomized, double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the treatment of moderate-to-severe plaque psoriasis. METHODS We randomly assigned patients with a score of 12 or higher on the psoriasis area-and-severity index (PASI, on which scores range from 0 to 72, with higher scores indicating more severe disease) and with 10% or more of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 372 CITATIONS

Apremilast for the treatment of psoriatic arthritis.

  • Expert review of clinical pharmacology
  • 2014
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Investigational drugs for treating psoriatic arthritis.

  • Expert opinion on investigational drugs
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pathogenic role of IL-17 in psoriasis and psoriatic arthritis.

  • Actas dermo-sifiliograficas
  • 2014
VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 23 Highly Influenced Citations

  • Averaged 33 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Blockade of the IL-17R with AMG 827 leads to rapid reversal of gene expression and histopathologic abnormalities in psoriatic skin, including substantial pathwayspecific effects within one week

C Russell, K Kerkof, J Bigler
  • J Invest Dermatol 2011;131:S11. abstract
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Blockade of the IL-17R with AMG 827 leads to rapid reversal of gene expression and histopathologic abnormalities in human psoriatic skin

C Russell, K Kerkof, J Bigler
  • J Invest Dermatol
  • 2010
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…