Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

@article{Hansen1991BroadlyNA,
  title={Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.},
  author={J. E. S. Hansen and Claus Meyer Nielsen and M. Arendrup and S. Olofsson and Lars R. Mathiesen and Jens O. Nielsen and Henrik Clausen},
  journal={Journal of virology},
  year={1991},
  volume={65 12},
  pages={6461-7}
}
The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious… CONTINUE READING