Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

@inproceedings{Wiesch2012BroadlyDV,
  title={Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence},
  author={Julian Schulze zur Wiesch and Donatella Ciuffreda and Lia Laura Lewis-Ximenez and Victoria Kasprowicz and Brian E. Nolan and Hendrik Streeck and Jasneet Aneja and Laura L. Reyor and Todd M. Allen and Ansgar Wilhelm Lohse and Barbara G McGovern and Raymond Tsang Chi Chung and William W Kwok and Arthur Y. Kim and Georg M Lauer},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
Vigorous proliferative CD4(+) T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we comprehensively characterized the breadth, specificity, and quality of the HCV-specific CD4(+) T cell response in 31 patients with acute HCV infection and varying clinical outcomes. We analyzed in vitro T cell expansion in the presence of interleukin-2, and ex vivo staining with… CONTINUE READING

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