Broadband cortical desynchronization underlies the human psychedelic state.

  title={Broadband cortical desynchronization underlies the human psychedelic state.},
  author={Suresh D. Muthukumaraswamy and Robin L Carhart-Harris and Rosalyn J. Moran and Matthew J. Brookes and Tim M. Williams and David Errtizoe and Ben Sessa and Andreas Papadopoulos and Mark Bolstridge and Krish D. Singh and Amanda Feilding and Karl J. Friston and David J. Nutt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 38},
Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded in healthy human participants with magnetoencephalography after intravenous infusion of psilocybin--prodrug of the nonselective serotonin 2A receptor agonist and classic psychedelic psilocin. Psilocybin reduced spontaneous cortical oscillatory power from 1 to 50 Hz in posterior association cortices, and from… CONTINUE READING
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