Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo.

  title={Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo.},
  author={David John Grainger and Jill Reckless},
  journal={Biochemical pharmacology},
  volume={65 7},
Inappropriate inflammation is a component of a wide range of human diseases, including autoimmune disease, atherosclerosis, osteoporosis and Alzheimer's disease. Chemokines play an important role in orchestrating leukocyte recruitment during inflammation, and therefore represent an important target for anti-inflammatory therapies. Unfortunately, the chemokine system is complex, with about 50 ligands and 20 receptors, often acting with redundancy, making selection of appropriate specific… CONTINUE READING

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