Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.

  title={Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.},
  author={Hans-Heinrich Hoffmann and Andrea Kunz and Viviana A Simon and P. Palese and Megan L Shaw},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 14},
Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown to inhibit the replication of negative-sense RNA viruses (influenza viruses A and B, Newcastle disease virus, and vesicular stomatitis virus), positive-sense RNA viruses (Sindbis virus, hepatitis C virus, West Nile virus, and dengue virus), DNA viruses (vaccinia virus and human adenovirus), and… CONTINUE READING
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