Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial
@article{Kenyon2001BroadspectrumAF, title={Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial}, author={Sarah Kenyon and David J. Taylor and William Odita Tarnow-Mordi}, journal={The Lancet}, year={2001}, volume={357}, pages={979-988} }
620 Citations
ORACLE—antibiotics for preterm prelabour rupture of the membranes: short‐term and long‐term outcomes
- MedicineActa paediatrica (Oslo, Norway : 1992). Supplement
- 2002
Indications of short‐term respiratory function, chronic lung disease and major neonatal cerebral abnormality were reduced with the prescription of erythromycin, and the use of co‐amoxiclav was associated with a significant increase in the occurrence of neonatal necrotizing enterocolitis.
Antibiotic therapy for preterm premature rupture of membranes – results of a multicenter study
- MedicineJournal of perinatal medicine
- 2006
Antibiotic administration following preterm premature rupture of membranes is associated with a prolongation of pregnancy and a reduction of neonatal infectious morbidity.
Antibiotics for preterm premature rupture of membranes.
- MedicineThe Cochrane database of systematic reviews
- 2001
The use of antibiotics following preterm prelabour rupture of membranes (pPROM) is associated with a statistically significant reduction in maternal infection after delivery prior to discharge and there are fewer data relating to specific antibiotics.
Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
- MedicineJournal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
- 2022
Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics
- MedicineBMC Research Notes
- 2012
Latency period of PPROM after using prophylactic antibiotics and antenatal corticosteroids increased while neonatal infectious morbidity was low, but maternal infectious morbidities was not increased.
Preterm premature rupture of the membranes at 22 weeks: problem-based approach
- Medicine
- 2001
The aim would be to prolong pregnancy through conservative management to achieve maximum fetal maturity prior to delivery without the onset of chorioamnionitis or neonatal sepsis.
Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis.
- MedicineAmerican journal of obstetrics and gynecology
- 2008
The effect of non‐penicillin antibiotic regimens on neonatal outcomes in preterm prelabor rupture of membranes: 7
- MedicineAmerican Journal of Obstetrics and Gynecology
- 2018
Antibiotics for preterm rupture of membranes.
- MedicineThe Cochrane database of systematic reviews
- 2013
Routine prescription of antibiotics for women with preterm rupture of the membranes is associated with prolongation of pregnancy and improvements in a number of short-term neonatal morbidities, but no significant reduction in perinatal mortality.
Pseudomembranous colitis, a complication of erythromycin and preterm prelabour rupture of membranes
- MedicineBJOG : an international journal of obstetrics and gynaecology
- 2006
A 36-year-old primigravida, booked for low-risk antenatal care, sustained preterm prelabour rupture of membranes (pPROM) at 31 weeks and 5 days of gestation, the diagnosis being confirmed on speculum…
References
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The use of antibiotics following preterm prelabour rupture of membranes (pPROM) is associated with a statistically significant reduction in maternal infection after delivery prior to discharge and there are fewer data relating to specific antibiotics.
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regional differences have two important implications in that: (i) the cervical membrane may represent a region of structural weakness susceptible to rupture during labour, and (ii) the paracrine relationships between fetal membranes and the myometrium may be qualitatively affected within different regions of the uterus.
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This review provides a summary and commentary on recent works on management of PROM, which remains a major dilemma within the last decade.
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The strong relationship between preterm delivery before 30 weeks gestation and infection offers the possibility of a unifying hypothesis connecting both delivery and brain injury, but at present the data to support a role for intrauterine infection in human cerebral damage are largely circumstantial and to some degree inconsistent.
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Of the major predictors of low birth weight, only prolonged rupture of membranes, chorionitis, and congenital malformations contributed to the risk of cerebral palsy beyond their contribution to therisk of low Birth weight.