Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial

@article{Kenyon2001BroadspectrumAF,
  title={Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial},
  author={Sarah Kenyon and David J. Taylor and William Odita Tarnow-Mordi},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={979-988}
}

Tables from this paper

ORACLE—antibiotics for preterm prelabour rupture of the membranes: short‐term and long‐term outcomes

Indications of short‐term respiratory function, chronic lung disease and major neonatal cerebral abnormality were reduced with the prescription of erythromycin, and the use of co‐amoxiclav was associated with a significant increase in the occurrence of neonatal necrotizing enterocolitis.

Antibiotic therapy for preterm premature rupture of membranes – results of a multicenter study

Antibiotic administration following preterm premature rupture of membranes is associated with a prolongation of pregnancy and a reduction of neonatal infectious morbidity.

Antibiotics for preterm premature rupture of membranes.

The use of antibiotics following preterm prelabour rupture of membranes (pPROM) is associated with a statistically significant reduction in maternal infection after delivery prior to discharge and there are fewer data relating to specific antibiotics.

Antibiotics for Preterm Rupture of the Membranes: A Systematic Review

The administration of antibiotics after PROM is associated with a delay in delivery and a reduction in maternal and neonatal morbidity, and these data support the routine use of antibiotics for women with PROM.

Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics

Latency period of PPROM after using prophylactic antibiotics and antenatal corticosteroids increased while neonatal infectious morbidity was low, but maternal infectious morbidities was not increased.

Antibiotics for preterm rupture of membranes.

Routine prescription of antibiotics for women with preterm rupture of the membranes is associated with prolongation of pregnancy and improvements in a number of short-term neonatal morbidities, but no significant reduction in perinatal mortality.

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  • 2006
A 36-year-old primigravida, booked for low-risk antenatal care, sustained preterm prelabour rupture of membranes (pPROM) at 31 weeks and 5 days of gestation, the diagnosis being confirmed on speculum
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References

SHOWING 1-10 OF 44 REFERENCES

Antibiotics for preterm premature rupture of membranes.

The use of antibiotics following preterm prelabour rupture of membranes (pPROM) is associated with a statistically significant reduction in maternal infection after delivery prior to discharge and there are fewer data relating to specific antibiotics.

VaginalUreaplasma urealyticum colonization: Influence on pregnancy outcome and neonatal morbidity

It is concluded that maternal U. urealyticum colonization is associated with amnionitis, chorioamnionitis and preterm delivery, and that tracheal colonization withU.

Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years.

Antenatal exposure to intra-amniotic inflammation and evidence of a systemic fetal inflammatory response (funisitis) are strong and independent risk factors for the subsequent development of cerebral palsy at the age of 3 years.

Maternal infection and cerebral palsy in infants of normal birth weight.

Intrauterine exposure to maternal infection was associated with a marked increase in risk of CP in infants of normal birth weight and was linked with low Apgar scores, other evidence of hypotension [corrected] and need for resuscitation, and neonatal seizures-signs commonly attributed to birth asphyxia.

Structural characteristics of term human fetal membranes prior to labour: identification of an area of altered morphology overlying the cervix.

regional differences have two important implications in that: (i) the cervical membrane may represent a region of structural weakness susceptible to rupture during labour, and (ii) the paracrine relationships between fetal membranes and the myometrium may be qualitatively affected within different regions of the uterus.

Premature Rupture of the Membranes

This review provides a summary and commentary on recent works on management of PROM, which remains a major dilemma within the last decade.

Placental inflammation and brain injury in preterm infants

  • P. Duggan
  • Medicine, Biology
    Developmental medicine and child neurology. Supplement
  • 2001
The strong relationship between preterm delivery before 30 weeks gestation and infection offers the possibility of a unifying hypothesis connecting both delivery and brain injury, but at present the data to support a role for intrauterine infection in human cerebral damage are largely circumstantial and to some degree inconsistent.