Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial

@article{Kenyon2001BroadspectrumAF,
  title={Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial},
  author={Sarah Kenyon and David J. Taylor and William Odita Tarnow-Mordi},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={979-988}
}

Tables from this paper

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References

SHOWING 1-10 OF 44 REFERENCES

Antibiotics for preterm premature rupture of membranes.

The use of antibiotics following preterm prelabour rupture of membranes (pPROM) is associated with a statistically significant reduction in maternal infection after delivery prior to discharge and there are fewer data relating to specific antibiotics.

Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years.

Antenatal exposure to intra-amniotic inflammation and evidence of a systemic fetal inflammatory response (funisitis) are strong and independent risk factors for the subsequent development of cerebral palsy at the age of 3 years.

Maternal infection and cerebral palsy in infants of normal birth weight.

Intrauterine exposure to maternal infection was associated with a marked increase in risk of CP in infants of normal birth weight and was linked with low Apgar scores, other evidence of hypotension [corrected] and need for resuscitation, and neonatal seizures-signs commonly attributed to birth asphyxia.

Structural characteristics of term human fetal membranes prior to labour: identification of an area of altered morphology overlying the cervix.

regional differences have two important implications in that: (i) the cervical membrane may represent a region of structural weakness susceptible to rupture during labour, and (ii) the paracrine relationships between fetal membranes and the myometrium may be qualitatively affected within different regions of the uterus.

Premature Rupture of the Membranes

This review provides a summary and commentary on recent works on management of PROM, which remains a major dilemma within the last decade.

Placental inflammation and brain injury in preterm infants

  • P. Duggan
  • Medicine, Biology
    Developmental medicine and child neurology. Supplement
  • 2001
The strong relationship between preterm delivery before 30 weeks gestation and infection offers the possibility of a unifying hypothesis connecting both delivery and brain injury, but at present the data to support a role for intrauterine infection in human cerebral damage are largely circumstantial and to some degree inconsistent.

Predictors of low and very low birth weight and the relation of these to cerebral palsy.

Of the major predictors of low birth weight, only prolonged rupture of membranes, chorionitis, and congenital malformations contributed to the risk of cerebral palsy beyond their contribution to therisk of low Birth weight.