Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial

@article{Kenyon2001BroadspectrumAF,
  title={Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial},
  author={S Kenyon and Dj Taylor and William Odita Tarnow-Mordi and for the Oracle Collaborative Group},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={979-988}
}
  • S Kenyon, Dj Taylor, +1 author for the Oracle Collaborative Group
  • Published 2001
  • Medicine
  • The Lancet
  • BACKGROUND Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue. METHODS 4826 women with pPROM were randomly assigned 250 mg erythromycin (n=1197), 325 mg co-amoxiclav (250 mg… CONTINUE READING

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