Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations.

@article{Smith2010BroadspectrumAA,
  title={Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations.},
  author={Peter A. C. Smith and Tucker C. Roberts and Floyd E Romesberg},
  journal={Chemistry & biology},
  year={2010},
  volume={17 11},
  pages={1223-31}
}
Novel classes of broad-spectrum antibiotics are needed to treat multidrug-resistant pathogens. The arylomycin class of natural products inhibits a promising antimicrobial target, type I signal peptidase (SPase), but upon initial characterization appeared to lack whole-cell activity against most pathogens. Here, we show that Staphylococcus epidermidis, which is sensitive to the arylomycins, evolves resistance via mutations in SPase and that analogous mutations are responsible for the natural… CONTINUE READING

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