Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis.

@article{Zeng2012BroadRH,
  title={Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis.},
  author={Xiankun Zeng and Steven X. Hou},
  journal={Development},
  year={2012},
  volume={139 21},
  pages={3917-25}
}
Like the mammalian intestine, the Drosophila adult midgut is constantly replenished by multipotent intestinal stem cells (ISCs). Although it is well known that adult ISCs arise from adult midgut progenitors (AMPs), relatively little is known about the mechanisms that regulate AMP specification. Here, we demonstrate that Broad (Br)-mediated hormone signaling regulates AMP specification. Br is highly expressed in AMPs temporally during the larva-pupa transition stage, and br loss of function… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
7 Citations
50 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Expression and function of the ultraspiracle ( usp ) gene during development of Drosophila melanogaster

  • J. Huang, L. Tian, +5 authors J. Wang
  • Dev . Biol .
  • 2011

Similar Papers

Loading similar papers…