Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.

@article{Romano2002BroadNR,
  title={Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.},
  author={Laura Romano and Giulietta Venturi and Stuart Bloor and Richard Harrigan and Brendan Larder and Jennifer C. Major and Maurizio Zazzi},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 7},
  pages={898-904}
}
Two large, independent human immunodeficiency virus type 1 resistance databases containing >7700 reverse-transcriptase (RT) sequences were used to analyze the epidemiology of amino acid substitutions at codons 44 and 118, which confer moderate lamivudine resistance in the presence of zidovudine resistance. As expected, E44A/D and V118I mutations were strongly associated with M41L, D67N, L210W, and T215Y but also with other mutations, including K43E/N/Q, T69D, V75M, H208Y, R211K, and K219R. Both… CONTINUE READING

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Quantitative prediction of HIV-1 phenotypic drug resistance from genotypes: the virtual phenotype [abstract 63

  • BA Larder, SD Kemp, K Hertogs
  • Antiviral Ther 2000;5(Suppl 3):49
  • 2002
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