Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region.

Abstract

We identified three cross-neutralizing plasma samples with high-titer anti-membrane proximal external region (MPER) peptide binding antibodies from among 156 chronically human immunodeficiency virus type 1-infected individuals. In order to establish if these antibodies were directly responsible for the observed neutralization breadth, we used MPER-coated… (More)
DOI: 10.1128/JVI.01359-09

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@article{Gray2009BroadNO, title={Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region.}, author={Elin Solomonovna Gray and Maphuti C. Madiga and Penny L Moore and Koleka Mlisana and Salim S. Abdool Karim and James M. Binley and George M. Shaw and John R. Mascola and Lynn Morris}, journal={Journal of virology}, year={2009}, volume={83 21}, pages={11265-74} }